Try with a clean install. New folder which only contains these files:
addons.bat
duke3d.grp
eac_install.bat
eduke32.exe
wget.exe
Also, create an empty text file called "user_profiles_disabled" and remove the .txt file ending. This way, cfg files are directly created and used in the local directory.
After that, execute eac_install, go through the installation process and run addons.bat afterwards. All assuming you use latest binaries and script release.

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