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The hint comes from CEO Randy Pitchford, responding to a fan's interest in a Duke Nukem-Gears of War crossover.
While it's unlikely it will be as straightforward as the tweet suggests (although, Gears of War 4 isn't exactly free of unusual cameos, considering it includes hip-hop duo Run the Jewels already), it does seem probable that the announcement will be made at The Game Awards, which take place on the same day.
It's long been suspected that Duke would be added to Gearbox's hero shooter Battleborn, which would satisfy the crossover criterion, but with Duke Nukem 3D celebrating its 20th anniversary, it wouldn't be all that surprising to learn that a new game in the series is on the way.
http://www.ign.com/a...ement-next-week
-edit sorry, I just noticed people were already talking about this in the World Tour thread