This crash occured when I hit "Load Game" but it was the same type of crash I've had twice on load screens and once during a level. Odd though, I didn't have any problems at all until I got into episode 2: Lunar Apocalypse. All my drivers are up to date, and though I'm using HRP, it comes with Polymer, though I updated to your latest version, released 3/11. eduke32.log is included on this post.
I'm also having an issue with 2 of the game.con errors, where it expects something else. If I run Duke w/o using eDuke or HRP (just execute duke3d.exe) it finds no errors. I normally wouldn't complain, except I edited user.con for increased ammo amounts, but since it finds errors in game.con it forces a default run of the con files in the .grp file.
Edit: I also had an odd issue on the Death Row level (E1 M3) where the wall explodes in the corridor, which opens up the room to the 2 turning gears, which you jump onto to get to a hidden room above.. Walk inside, I get insane FPS lag (1-2 FPS or so), continue to go inside, I get all kinds of graphical issues, back out and 0 FPS when I reach the red door which goes into the deeper complex.. I lost all form of control except "Shoot" and then after about 2 minutes, suddenly it went back to full speed, I turned around and went back into the room out of curiosity and no graphical problems, no loss of speed or control.. very odd, almost like a buffer issue. May be an issue with HRP, but had to be pretty bad to slow a Phenom quad core with a GeForce9800GTX on 4 gigs of system memory.