EDuke32 locks up erratically in Windows 7, with or without Polymer enabled. It's hard to reproduce because it doesn't always happen at the same point. Sometimes it'll happen a few levels into an episode, sometimes it happens when I close EDuke32. When it happens, I have to manually kill the process. Don't know if this matters, but Windows always mentions something about 'ntdll.dll'.
I have a GeForce GTX 260 w/ the latest drivers for Win 7.
A log from a recent crash is attached (polymer was enabled this time). For this log, I got as far as E1L3.