I'd partly agree with Dr. Panico regarding
The Queen being the most difficult from original maps; also, I think
Warp Factor deserves a mention as it can be really tricky pistol starting since you're pitted against some drones right at the start. For first time players,
The Abyss also can be difficult due to easily getting lost there.
Zarathustra wasn't as hard as the final level of
Blast Radius IMO, I also liked it a lot more than the latter. It just can be very inconvenient at the beginning, but settles relatively quickly (given its whole length). As for other user maps, then probably something like
Glitches in the System which I gave up on even despise following a video tutorial